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103,104 Both trials concluded that early therapy in asymptomatic individuals wasn't associated with a prolonged Total survival. Very just lately, preliminary results from a 3rd demo evaluating ibrutinib vs .

Deep, specific upcoming-era sequencing has uncovered that subclonal mutations (i.e., These present in just a portion of tumor cells) could be detected for all driver genes and therefore are associated with immediate disorder development and lousy outcome.11–thirteen This is especially applicable for TP53

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translocations or amplifications in addition to the genomic alterations by now current in the initial CLL, but lack the popular mutations noticed in Major DLBCL indicating that they may correspond to another biological category.

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